Abstracts
The effect of Cassis occidentalis Linn seed extract on body weight and lipid parameters (serum cholesterol, triglyceride, low density lipoprotein and high density lipoprotein) of rats fed with high fat diet (HFD) were investigated. The HFD was formulated using standard protocols and was used to feed the rats for 28 days. Crude extract of Cassia occidentalis Linn seed was administered at four different dose levels (250, 500, 750 and 1000 mg/kgbwt) to the experimental group. The result showed significant increase in body weight when HFD was administered to the rats. However, the administration of the extracts at various concentrations decreased the body weight of the rats significantly (P<0.05) for four weeks with the highest reduction observed at 750 mg/kg and 1000 mg/kg concentrations. The serum lipid parameters revealed a significant (P<0.05) decrease in the serum total cholesterol as the dose of the extract increases with concurrent increase in the high density lipoproteins (HDL) cholesterol which differ significantly with the normal control (P<0.05). Reduction in the content of low density lipoproteins (LDL) cholesterol and triglycerides were also observed to differ significantly (P<0.05) with the normal and experimental controls. The result suggests that the seed extract of the plant is an anti-atherosclerosis and an acute anti-obesity therapy which could be used in the regulation of lipid without detecting any adverse effect.
Keywords :Cassia occidentalis linn; lipid parameter; serum cholesterol; HFD; HDL; LDL.
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